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Update: adjuncts to mechanical ventilation.

Identifieur interne : 000274 ( Main/Exploration ); précédent : 000273; suivant : 000275

Update: adjuncts to mechanical ventilation.

Auteurs : Gustavo A. Cortes [États-Unis] ; John J. Marini

Source :

RBID : pubmed:22228420

Descripteurs français

English descriptors

Abstract

PURPOSE OF REVIEW

To describe the most recent advances and clinical applications of adjunctive techniques in mechanical ventilation, focusing on their overall impact on mortality and their potential indications in critically ill patients.

RECENT FINDINGS

The modern variants of extracorporeal membrane oxygenation are not only rescue alternatives but also therapeutic options for patients with severe but potentially reversible acute respiratory distress syndrome. Prone positioning returns as a desirable therapeutic option for patients with severe acute respiratory distress syndrome. Recent reports suggest that permissive hypercapnia, therapeutic paralysis, sedation, and controlled hypothermia could potentially improve important clinical outcomes. Although more clinical trials are clearly needed to support the use of inhaled prostacyclins in severe respiratory failure, encouraging results have been described in recent publications.

SUMMARY

Giving the complexity and dynamism of acute lung injury, timing, severity, and pathophysiologic pertinence are mandatory components of decision-making when considering the application of adjunctive measures to support mechanical ventilation.


DOI: 10.1097/ACO.0b013e32834f8c65
PubMed: 22228420


Affiliations:


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Le document en format XML

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<title xml:lang="en">Update: adjuncts to mechanical ventilation.</title>
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<name sortKey="Cortes, Gustavo A" sort="Cortes, Gustavo A" uniqKey="Cortes G" first="Gustavo A" last="Cortes">Gustavo A. Cortes</name>
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<nlm:affiliation>Department of Pulmonary and Critical Care, University of Minnesota, Regions Hospital, St. Paul, Minnesota, USA. Gustavo.A.CortsPuentes@HealthPartners.com</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pulmonary and Critical Care, University of Minnesota, Regions Hospital, St. Paul, Minnesota</wicri:regionArea>
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<term>Acute Lung Injury (therapy)</term>
<term>Extracorporeal Membrane Oxygenation (MeSH)</term>
<term>High-Frequency Ventilation (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Hypercapnia (physiopathology)</term>
<term>Neuromuscular Blocking Agents (therapeutic use)</term>
<term>Nitric Oxide (administration & dosage)</term>
<term>Prone Position (MeSH)</term>
<term>Pulmonary Gas Exchange (MeSH)</term>
<term>Respiration, Artificial (methods)</term>
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<term>Respiratory Distress Syndrome, Adult (therapy)</term>
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<term>Lésion pulmonaire aigüe (thérapie)</term>
<term>Monoxyde d'azote (administration et posologie)</term>
<term>Oxygénation extracorporelle sur oxygénateur à membrane (MeSH)</term>
<term>Syndrome de détresse respiratoire de l'adulte (thérapie)</term>
<term>Ventilation artificielle (mortalité)</term>
<term>Ventilation artificielle (méthodes)</term>
<term>Ventilation à haute fréquence (MeSH)</term>
<term>Échanges gazeux pulmonaires (MeSH)</term>
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<term>Nitric Oxide</term>
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<term>Monoxyde d'azote</term>
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<term>Respiration, Artificial</term>
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<term>Ventilation artificielle</term>
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<term>Ventilation artificielle</term>
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<term>Hypercapnie</term>
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<term>Hypercapnia</term>
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<term>High-Frequency Ventilation</term>
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<term>Prone Position</term>
<term>Pulmonary Gas Exchange</term>
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<term>Décubitus ventral</term>
<term>Humains</term>
<term>Oxygénation extracorporelle sur oxygénateur à membrane</term>
<term>Ventilation à haute fréquence</term>
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<b>PURPOSE OF REVIEW</b>
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<p>To describe the most recent advances and clinical applications of adjunctive techniques in mechanical ventilation, focusing on their overall impact on mortality and their potential indications in critically ill patients.</p>
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<b>RECENT FINDINGS</b>
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<p>The modern variants of extracorporeal membrane oxygenation are not only rescue alternatives but also therapeutic options for patients with severe but potentially reversible acute respiratory distress syndrome. Prone positioning returns as a desirable therapeutic option for patients with severe acute respiratory distress syndrome. Recent reports suggest that permissive hypercapnia, therapeutic paralysis, sedation, and controlled hypothermia could potentially improve important clinical outcomes. Although more clinical trials are clearly needed to support the use of inhaled prostacyclins in severe respiratory failure, encouraging results have been described in recent publications.</p>
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<b>SUMMARY</b>
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<p>Giving the complexity and dynamism of acute lung injury, timing, severity, and pathophysiologic pertinence are mandatory components of decision-making when considering the application of adjunctive measures to support mechanical ventilation.</p>
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